The Main Library in Manila is the hub of the entire system of libraries in the campus. It is the largest among the libraries in the system. It has sections for Circulation, Reserve, CCSS Library, Acquisitions, Cataloging, Reference, Filipiniana, and Periodicals, which are housed on the second, third and fourth floors of the POD-CIT Building.

The book and serial collections continue to grow and are also being enriched with a growing collection of materials in various media and formats such as CD-ROMs, online databases and access to the Internet. Bibliographic access to the library collections is through the Online Public Access Catalog (OPAC) terminals available in all the libraries